Metotrexato ≥98%, orange powder USP

Proveedor: MP Biomedicals
Danger

Sinónimos: (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

0210229991 0210229910 0210229925 0210229980 0210229990
ICNA0210229991EA 1644 EUR
ICNA0210229991 ICNA0210229910 ICNA0210229925 ICNA0210229980 ICNA0210229990
Metotrexato ≥98%, orange powder USP
Metotrexato

Folic Acid antagonist; structurally similar to folic acid. Methotrexate is a mixture of 4-amino-10-methylfolic acid and closely related compounds.


A potent anticancer agent. Blocks DNA synthesis by blocking the production of tetrahydrofolate cofactors required for the synthesis of thymidine. Methotrexate is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folypolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Methotrexate-polyglutamate is degraded intracellularly by gamma-glutamyl hydrolase.


Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.


Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.


Soluble in alkaline solutions with decomposition. Insoluble in water, ethanol, chloroform and ether.

Formula: C₂₀H₂₂N₈O₅
MW: 454,44 g/mol
Temperatura de almacenaje: Refrigerator
Número MDL: MFCD00150847
Núm. CAS: 59-05-2
EINECS: 200-413-8
UN: 2811
ADR: 6.1,III

Order Now

Resultados test especificaciones

Identity Test A Passes
Identity Test B Passes
Specific Rotation (anhydrous basis) +19° to +24°
Water ≤12%
Residue on Ignition ≤0.1%
Methotrexate Content (anhydrous basis as C20H22N8O5) 98 - 102%

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Más About VWR