Brefeldin A ≥98% (by TLC)

Proveedor: Enzo Life Sciences

ALEXBML-G405-0100EA 1117 EUR
ALEXBML-G405-0100 ALEXBML-G405-0025 ALEXBML-G405-0005
Brefeldin A ≥98% (by TLC)
Brefeldin A

GEF inhibitor


Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.


Isolated from Eupenicillium brefeldianum.

Formula: C₁₆H₂₄O₄
MW: 280,4 g/mol
Número MDL: MFCD00083258
Núm. CAS: 20350-15-6
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