Anti-Acute-phase response factor Mouse Monoclonal Antibody [clone: 1D11]

Proveedor: Biosensis
BSENM-870-100EA 327 EUR
BSENM-870-100
Anti-Acute-phase response factor Mouse Monoclonal Antibody [clone: 1D11]
Anticuerpos
Acute-phase response factor (STAT3) is a transcription factor that binds to the IL-6-responsive elements identified in the promoters of various acute-phase protein genes. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Once phosphorylated, the protein is translocated into the nucleus. It forms a homodimer or a heterodimer with a related family member (STAT1). It is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Defects in Acute-phase response factor are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES). This disorder is  characterised by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.

Specificity has been confirmed by WB and direct ELISA against the antigen.
Application Information:
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: Acute-phase response factor
Clonality: Monoclonal
Clone: 1D11
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human
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