Anti-Notch 2 Mouse Polyclonal Antibody

Proveedor: Biosensis
BSENMO-933-50EA 327 EUR
BSENMO-933-50
Anti-Notch 2 Mouse Polyclonal Antibody
Anticuerpos
Notch 2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. It is expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Defects in Nothch 2 are the cause of Alagille syndrome type 2 which is a multisystem disorder defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal and opthalmologic manifestations.

Specificity has been confirmed by WB and direct ELISA against the antigen.
Application Information:
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: Notch 2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Human Notch 2 (26-136)
Host: Mouse
Isotype:
Reactivity: Human
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