Anti-alpha synuclein Sheep Polyclonal Antibody

Proveedor: Biosensis
BSENS-078-50EA 334 EUR
BSENS-078-50
Anti-alpha synuclein Sheep Polyclonal Antibody
Anticuerpos
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.

Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by western blot.
Application Information:
IHC. Recommended to be used at a concentration of 1 µg/ml for immunohistochemistry (Paraffin sections). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: alpha synuclein
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: aa: 108-120
Host: Sheep
Isotype: IgG
Reactivity: Human, Rat
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