PA1-16953 is specific for the ~58 kDa LOX protein. This is a highly glycosylated protein and therefore, other bands may be seen at ~32 kDa (non-glycosylated form) 50 kDa and 58 kDa (glycosylated forms). Suggested positive control: human and mouse kidney lysate, antigen standard for LOX (transient overexpression lysate), human kidney protein, mouse kidney protein. Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.
Type: Primary
Antigen: LOX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Human